院長簡介
姓名： 楊堉麟 教授 (Yang Yu-Lin, PhD, Professor)
專線：（06）2674567*650
傳真：（06）2693348
信箱：call0955443221@gmail.com
現職 (Present job)
中華醫事科技大學 醫事學院院長 (2021.8.至今)
中華醫事科技大學 醫學檢驗暨生物技術系教授 / 生物醫學研究所教授 (2008-至今)
學經歷 (Education)
高雄醫學大學醫學技術學系畢業, 直升醫學研究所碩士 , 直升醫學研究所博士
高雄醫學大學醫學研究所博士第一名畢業 (併獲年度博士優秀論文獎)
澳洲昆士蘭大學生物醫學研究所 交換學者 臺澳雙邊計畫（澳洲皇家科學院補助）
經歷 (Experience)
擔任TIPPA及WIIPA（世界發明智慧財產聯盟總會）國際評審（2018-2021）
受邀擔任政府醫事公職人員命題典試委員（2018）
台澳雙邊計畫 (102WMRFDD500008) 澳洲昆士蘭大學生物醫學研究所訪問教授 (2013)
行政院科技部 (原國科會) 科技專題計畫學術審查委員 (2013-2017)
教育部 學術審查委員會外審委員
中華醫事科技大學 副校長 (2015.6-2020)
中華醫事科技大學教務處 教務長 (2013-2020)
擔任南科管理局研發精進計畫審查委員(2011)
中華醫事科技大學學生事務處 學生事務長 (2008-2013)
高雄醫學大學校友總會 理事/ 榮譽理事 (2008-2014)
教育部南區區域教學資源中心委員 (2008-2011)
高雄醫學大學醫學技術學系校友會會長 (2007-2009)
中華醫事科技大學生物醫學研究所 創所暨籌備所長 (2007)
台南市與台南縣 SBIR計畫審查委員 (2007-2000)
中華醫事科技大學生物安全委員會主任委員 (2004-2013)
中華醫事科技大學生物科技系創系系主任 (2002-2007)
榮譽 (Honor)
獲選教育部107年度 師鐸獎(teacher of the year) 2018
(註：全國大學僅8位入選) ※106年師鐸獎－楊堉麟教授
參與中華民國世界發明家競賽獲得第二屆國家品質菁英獎
獲教育部科技校院提升務專業管理能力計畫 (連獲2年500萬)
獲教育部教學卓越計畫 (全國新進教學卓越學校第一名)
獲2013年度第13屆馬來西亞國際發明展ITEX發明競賽金牌
獲教育部全國大專院校友善校園績優學校
獲教育部全國學生事務評鑑一等佳績
獲科技部傑出優秀學者養成計畫補助
獲教育部第一屆全國大學特殊優秀人才彈性薪資獎勵
獲教育部全民國防教育評鑑一等績優學校
推動品德教育獲教育部全國品德教育績優學校
獲選教育部全國唯一連獲六年全國大學頂尖研發人才實施特殊優秀人才彈性薪資補助
(註：全國獲選率 6%, 生技生醫領域為全國私校唯一獲獎)
獲選國科會獎勵特殊優秀人才措施之計畫核定 (99年度, 102年度)
行政院國科會專案研究計畫連續 12 年獲補助 (2001-2012)
獲選國科會三年期(99-101)傑出學者養成計畫 (99-2628-B-273-001-MY3)
(註：獲補助金額 4,110,000 元 為全國私立科大補助金額最高)
教育部產業園區產學專案計畫計畫主持人連獲 3 年補助 (2008-2010)
行政院國科會腎臟內分泌學門全國計畫排名第一 (2004)
教育部發展學校重點特色專案計畫主持人(2001,2002)
Professor Yang Yu-Lin (Ph.D.-medicine),Vice president from Chung Hwa University of Medical Technology, Taiwan.He got his B Sc in the department of biomedical laboratory Science and Medicine Doctor's degree (Ph.D.) at Graduate Institute of Medicine in Kaohsiung Medical University in year 2000 with outstanding medical phD thesis award.
As a specialist in Biomedical Science, he is the pioneer director for the Department of biomedical science and institute of biomedical science in Chung Hwa University of Medical Technology.
He is the chairman for Biological Safety Council and Biomedical Science research group in the University.
He is also the Editorial Board Member in Journal of Biotechnology & Biomaterials (OMICS Publishing Group, Los Angeles) and contributing editor in American Journal of Biochemistry and Biotechnology.
He is invited as reviewers for many journals (including International academic Journal, Journal of Dermatological Science, Acta Pharmacologica Sinica, Journal of Pediatric Biochemistry, International Journal for Biotechnology and Molecular Biology Research).
He is also invited as an advisor for Small Business Innovation Research (SBIR) Program Review Committee for Tainan city government and advisor for Kaohsiung Biotechnology Science Park in Taiwan.
Prof. Yang has recently been honored and elected as the outstanding researcher Award in 2010 in Taiwan (Top 6% in Taiwan), and being elected as a distinguished young scholarship 3-year grands by National Science Council.
Under the support of Australia Academy of Science and National Science Council in Taiwan. He was invited as a visiting professor for University of Queensland (School of Biomedical Science, SBMS, Australia) in 2013.
He won Gold and Silver invention award in 13th international ITEX competition in Malaysia. The achievement in the invention of Osmanthus facial mask have been elected as the 2nd national quality assurance award in Taiwan.
Moreover, he was highly recommended as a teacher of the year in Taiwan from the ministry of Education, and been invited in person and awarded by President Tsai from Taiwan in 2017.
專業證照
以臨床生化滿分成績取得醫事檢驗師國家執照。發照單位：考選部。
特定化學物質作業主管證照。發照單位：中華民國工業安全衛生協會。
醫學實驗室認證規範ISO15189訓練合格證書。發照單位：財團法人全國認證基金會。
TQC-OA 辦公室軟體應用類專案管理證照 (2010/11/25) 級別: 專業級。
TQC-DK 專業知識領域, 電子商務概論 專案管理證照 (2010/11/25) 級別: 專業級。
國際期刊審查委員(Reviewer in SCI journals)
BMC Complementary and Alternative Medicine (2013, Mar)
Pharmacological Reports (2012, Dec)
Apoptosis (2012, Sep)
Clinical Biochemistry (2012, Apr)
Journal of Research in Environmental Science and Toxicology (2012, Jan)
African Journal of Microbiology Research (2011, Nov)
Journal of Medical Plants Research (2011, Oct)
International Journal of Fisheries and Aquaculture (2011, Aug)
Journal of Diabetes and Endocrinology (2011, June)
International Journal of Nutrition and Metabolism (2011, Jan)
Journal of Metabolomics and Systems Biology (2010, Nov)
International Journal for Biotechnology and Molecular Biology Research (2010, Oct)
Journal of Medicine and Medical Sciences (2010, Oct)
African Journal of Pharmacy and Pharmacology (2010, Sep)
Journal of Pediatric Biochemistry (member in the Reviewer Board, (2010 )
African Journal of Biotechnology (2010, May)
Acta Pharmacologica Sinica (2009)
Journal of Dermatological Science (2008)
Pharmacological Research (2007)
其他國際學術資歷
Book Authors: Yu-Lin Yang , Wen- Teng Chang and Yuan-Wei Shih, "Gene Therapy, Chapter title: Gene Therapy Using RNAi".
InTech (Open Access Publisher) [ISBN: 978-953-307-240-1] (2011)
Book Authors: entitled "Renal Diseases" InTech - Open Access Publisher [ISBN: 978-953-308-58-7] (2011)
Editorial Board Member in "Journal of Biotechnology & Biomaterials" (OMICS Publishing Group, Los Angeles CA-91362-7354, USA 2011)
Contributing Editor in American Journal of Biochemistry and Biotechnology
Consultancy: EPS Global Medical Development Inc. (2011)
Editor in the Journal of Steroids & Hormonal Science (2011)
審查委員
經濟部鼓勵中小企業開發新技術推動計畫(SBIR) 計畫審查委員
台南縣鼓勵中小企業開發新技術推動計畫(SBIR) 計畫審查委員
台南市鼓勵中小企業開發新技術推動計畫(SBIR) 計畫審查委員
教育部學術審查委員會升等審查委員
國科會專題計畫審查委員
擔任教學行政工作之具體績效
107年擔任副校長/教務長爭取教育部高教深耕計畫近四千萬
103年擔任教務長爭取教育部教學卓越計畫近三千五百萬
100年度本校獲大專院校友善校園學務與輔導績優學校南區43所大專院校中第一名(2011)
100年度本校獲全國友善校園學務與輔導績優學校(2011)
99年本校獲校務評鑑學務評鑑獲一等(2010)
98年度本人兼代軍訓室主任任內，本校獲全民國防教育評鑑一等績優學校(2009)
98-100年度導師輔導回饋成績績優(2009-2011)
97年本校獲得全國品德教育績優學校(2008)
科技與學術顧問
高雄市生物科技園區推動委員會專案顧問
台南縣政府創新育成中心生物科技技術顧問
屏東農科產業園區籌設委員之一
技術轉移
|
技術轉移案號 |
技轉名稱 |
技轉對象 |
技術權利 |
|
編號: C1020603008 |
山藥有效萃取物diosgenin對腎纖維化控制技術之平台 |
連宏實業有限公司 |
102年6月1日至103年5月31日 |
|
編號: C1010712011 (技10101002) |
以幹細胞平台開發纖維化控制技術之應用 |
啟瀚科技有限公司 |
101年7月15日至101年12月15日 |
|
編號: C1010303001 (技10101001) |
山藥萃取物對腎纖維化控制技術之應用 |
連宏實業有限公司 |
101年4月1日至101年10月1日 |
|
編號: 10001003 |
以免疫生長因子開發腎纖維化控制技 |
啟瀚科技有限公司 |
100年6月1日至100年12月1日 |
|
編號:10001002 |
開發酵素對抗腎纖維治療之平台 |
貫閎開發生技股份有限公司 |
100年1月1日至100年10月31日 |
|
編號:10001001 |
以北蟲草萃取液對抗腎纖維治療之開發 |
欣潤生物科技股份有限公司 |
100年1月1日至100年10月31日 |
個人專案研究計畫與研究方向
Professor Yang Yu-Lin (Ph.D.-medicine), now is Dean of Academic Affairs from Chung Hwa University of Medical Technology, Taiwan.
He got his B Sc in the department of biomedical laboratory Science and Medicine Doctor's degree (Ph.D.) at Graduate Institute of Medicine in Kaohsiung Medical University in 2000 with outstanding phD thesis award.
As a specialist in Biomedical Science, he is the pioneer director for the department of biomedical science and institute of biomedical science in Chung Hwa University of Medical Technology.
He is the chairman for Biological Safety Council and Biomedical Science research group in the University.
He is also the Editorial Board Member in Journal of Biotechnology & Biomaterials (OMICS Publishing Group, Los Angeles) and contributing editor in American Journal of Biochemistry and Biotechnology.
He is invited as reviewers for many journals (including International academic Journal, Journal of Dermatological Science, Acta Pharmacologica Sinica, Journal of Pediatric Biochemistry, International Journal for Biotechnology and Molecular Biology Research).
He is also invited as an advisor for Small Business Innovation Research (SBIR) Program Review Committee for Tainan city government and advisor for Kaohsiung Biotechnology Science Park in Taiwan.
Prof. Yang has recently been honored and elected as the outstanding researcher Award in 2010 in Taiwan (Top 6% in Taiwan), and being elected as a distinguished young scholarship 3-year grand (2010-2012) by National Science Council.
Under the support of Australia Academy of Science and National Science Council in Taiwan, he was invited as a visiting professor for University of Queensland (School of Biomedical Science, SBMS, Australia) in 2013.
現職及專長相關之經歷
|
服務機關 |
服務部門/系所 |
職稱 |
起訖年月 |
|
中華醫事科技大學 |
主任秘書室 |
主任秘書兼副校長 |
2020.8- |
|
經歷 ： |
|||
|
中華醫事科技大學 |
教務處 |
教務長兼副校長 |
2014.8-2020.7 |
|
中華醫事科技大學 |
學生事務處 |
教授兼任學生事務長 |
2008.8-2013.7 |
|
中華醫事科技大學 |
生物科技系暨生物醫學 研究所 |
副教授兼任系主任 (所長) |
2004.12-2008.7 |
|
中華醫事學院 |
生物科技系 |
副教授 |
2004.12 - |
|
中華醫事學院 |
生物科技系 |
副教授 |
2004.12 - |
|
高雄市政府 |
高雄生物科技園區推動 委員會 |
顧問 |
2002.09-2004.09 |
|
台南縣政府 |
創新育成中心 |
顧問 |
2002.09-2004.08 |
|
中華醫事學院 |
生物科技系 |
系主任 |
2002.07-2005.06 |
|
中華醫事學院 |
醫技系 |
生物科技系籌備主任 |
2002.02-2002.07 |
|
中華醫事學院 |
醫技系 |
助理教授 |
2000.08-2002.0 |
專利技術
|
專利案號 |
專利名稱 |
專利種類 |
申請(送件)時間 |
|
編號106131439 |
NRF-1蛋白質用以製備治療膀胱癌之藥物的用途 |
發明專利 |
2018-12-25核准 |
|
編號I527589 |
Nrf-1蛋白質之用途 |
發明專利 |
2016-04-01核准 |
|
編號PK14006 |
PGC-1A抑制劑之用途 |
發明專利 |
申請中 |
|
編號I494118 |
使用山藥植物(Dioscorea spp. plant)之經水萃取的產物來治療糖尿病腎病變 |
發明專利 |
2015-05-01核准 |
|
編號I444193 |
使用牛膝之經乙醇萃取的產物來治療肝纖維化 |
發明專利 |
2014-07-11核准 |
|
編號I442929 |
木樨植物治療肺纖維化 |
發明專利 |
2014-07-01核准 |
|
編號I421082 |
蛻皮激素用以製備治療腎纖維化藥物之用途及醫藥組合物用以製備治療腎纖維化之藥物的用途 |
發明專利 |
2014-01-01核准 |
|
編號I415621 |
介白素７用以製備治療腎纖維化藥物之用途及醫藥組合物用以製備治療腎纖維化之藥物的用 |
發明專利 |
2013-11-21核准 |
|
校內案號 C1020515008 |
輕便型快速微量吸管尖補充器 |
新型專利 |
2013-5-21 |
|
校內案號C1020515007 |
可變動式微量吸管尖盒 |
新型專利 |
2013-5-21 |
|
校內案號C1020528003 |
以DIOSGENIN調節腎細胞(近端腎小管)細胞纖維化 |
發明專利 |
2013-5-29 |
|
編號I386218 |
使用王不留行之經乙醇萃取的產物來治療糖尿病腎病變引發之腎纖維化 |
發明專利 |
2013-02-21核准 |
|
公開號201347766 |
使用木樨植物水萃產物來處理肺臟細胞纖維化 |
發明專利 |
2010-11-11 2012-5-28送件 2014-4-15通過 |
|
專利局申請碼PK12196 (核准案號I415612) |
Interleukin 7抑制腎纖維化之應用 |
發明專利 |
2011-07-12 2013-11-21通過 |
|
專利局申請碼PK12195 核准案號I421082 |
蛻皮激素作為藥物治療組織纖維化 |
發明專利 |
2011-07-12 2014-1-1通過 |
|
校內案號C0991111010 專利局申請案號101111701 |
杜牛膝萃取物對於抗肝纖維化治療之應用 |
發明專利 |
2010-11-11 2012-4-2送件 |
|
專利局申請碼 100209225 (核准案號M418288) |
可自行控制長度的微量分注器 |
新型專利 |
2010/12/30 2011/5/23送件 2011-12-11核准 |
|
專利局申請碼 100209226 (核准案號M413091) |
安全性酒精燈 |
新型專利 |
2010/12/30, 2011/5/23送件 2011-10-01核准 |
|
專利局申請碼 98120616 (核准案號201100089) |
使用山藥植物之經水萃取的產物來治療糖尿病腎病變 |
發明專利 |
2009/6/19送件 |
|
狀態 |
計畫主題（編號） |
計畫期限 |
核定計畫經費 |
|
執行中 |
師生與社區居民電子健康紀錄資料的收集分析 |
2020/07/10~2021/07/09 |
|
|
執行中 |
探討第一型和呼吸因子NRF-1與粒線體調節對肺癌治療的角色 |
2020/02/01~2022/01/31 |
1,200,000元 |
|
執行中 |
探討微粒/神經調節蛋白對腎纖維化調節的角色 |
2019/08/01~2020/07/31 |
850,000元 |
|
執行中 |
桂花純物質對於皮膚細胞功效分析與相關應用 |
2017/09/01~2019/08/31 |
|
|
申請中 |
探討微粒/神經調節蛋白對腎纖維化調節的角色科技部 |
|
|
|
申請中 |
探討紅景天活性物質透過miRNA對於膀胱癌治療的機制 |
|
|
|
結案 |
探討桂花有效物質調節前列腺癌之作用機制 |
2018/01/01~2018/12/31 |
200,000元 |
|
結案 |
探討去氫固醇於腎纖維化之治療應用 VHYK-015 |
2018/01/01~2018/12/31 |
500,000元 |
|
結案 |
在腎絲球足細胞下探討纖維化誘導因子（TGF-β1）刺激下ROS、 ER stress與粒線體生合成的交互作用 ( 106-2314-B-273 -001 -) |
2017/08/01~2018/07/31 |
科技部 850,000元 |
|
結案 |
探討粒線體生合成轉錄因子NRF-1於腎纖維化調節或治療上的角色(105-2314-B-273-002-) |
2016/08/01~2017/07/31 |
科技部計畫： [1,050,000元] |
|
結案 |
蛋白尿引發integrin-β3藉以增加腎絲球足細胞的移行 |
201/701/01~2017/12/31 |
300,000元 |
|
結案 |
探討粒線體生合成轉錄因子NRF-1於腎纖維化調節或治療上的角色 高雄榮總台南分院院長王志龍 （編號T009） |
2017/01/01~2017/12/31 |
748,572元 |
|
結案 |
產學計畫: 探討粒線體生合成轉錄因子PGC-1α於腎纖維化調節或治療上的角色（編號T001） 高雄榮總台南分院 外科主任 陳進旺 |
2017/01/01~2017/12/31 |
424,222元 |
|
結案 |
紅景天有效活性物質紅景天苷於膀胱纖維化保護功效評估Evaluation of the protective role of active Rhodiola rosea against bladder fibrosis. |
2016/01/01~2016/12/31 |
200,000元 |
|
結案 |
探討粒線體生合成因子NRF1之控制對於腎臟纖維化控制的角色 |
2015/12/01~2017/11/30 |
|
|
結案 |
教育部產學計畫: 開發運用三維介電泳微流體晶片技術於糖尿病視網膜病變的快速篩檢平台 |
2015/06/01~2016/05/31 |
|
|
結案 |
屏東區域產學補助產學研發亮點成果 探討IL-7於腎近端小管細胞纖維化的角色 |
2014/09/01~2014/12/31 |
|
|
結案 |
探討Diosgenin與能量感應訊息路徑AMPK/SIRT1/PGC-1於腎臟纖維化之調節角色與機轉 |
2014/08/01 ~ 2015/07/31 |
科技部計畫 [980,000元] |
|
結案 |
產學計畫: 探討能量調節蛋白PGC1alpha之控制對於腎臟纖維化控制的角色 |
2014/07/01~2016/10/31 |
|
|
結案 |
教育部產學計畫: 探討去氫固醇於肝纖維化之治療應用 |
2013/05/15~2014/12/31 |
|
|
結案 |
大學實施頂尖人才彈性薪資申請計畫 |
2013/08~2016/07/31 |
教育部計畫 |
|
結案 |
山藥活性物質Diosgenin之護肝功效評估 (103B-17-007, 聯群生技股份有限公司) (103年教育部產業園區產學合作計畫) |
2014/01/22 ~2014/12/31 (教育部) |
1,425,000元 (教育部675,000+學校150,000+ 企業600,000) |
|
結案 |
大學實施頂尖研發人才彈性薪資申請計畫 (全國唯一連獲6年彈性薪資計畫) |
2010/8 ~ 2016/07/31 (教育部) |
3,600,000元 (含校配合) |
|
結案 |
科技部補助大專校院獎勵特殊優秀人才計畫 (NSC 102－3114－C－273－001－ES) |
2013/08/01 ~ 2014/07/31 (科技部) |
732,442 (全校) 120,000 (個人) |
|
結案 |
教育部補助102學年度技職校院建立策略聯盟計畫 |
2013/08 ~2014/07 (教育部) |
364,000 + 72,800(配合款) |
|
結案 |
探討胸腺基質淋巴生成素於糖尿病腎臟病變的角色與抗纖維化之臨床應用（NSC 99-2628-B-273 -001 -MY3）行政院國科會傑出學者養成計畫(個別型) |
2010/08/01 ~ 2013/07/31 (國科會) |
4,110,000元 (全國私立科大補助金額最高) |
|
結案 |
以免疫治療方式對抗腎纖維化之功效 (連宏生技股份有限公司) |
2011/05/01~2011/07/31 (教育部產學合作計畫) |
60,000元 |
|
結案 |
活血中草藥發酵產物抗腎纖維化功效之開發 (貫閎開發生技股份有限公司) |
2011/01/01~2011/05/31 (教育部產學合作計畫) |
60,000元 |
|
結案 |
99年度南區區域教學資源中心計畫 (分項計畫三: 主持人) 提升學生學習成效促進室性發展 |
2010/02/01~2011/06/30 (教育部區域教學卓越計畫) |
約1,200,000元 |
|
結案 |
100年度南區區域教學資源中心計畫 (分項計畫三: 主持人)找自己:全方位發展與學習輔導關懷計畫 |
2011/07/01~2012/06/30 (教育部區域教學卓越計畫) |
2,449,040元 |
|
結案 |
遞補學生事務與輔導人力計畫 (教育部) |
2010/01/01~2010/12/31 |
4,771,750元 |
|
結案 |
比較未分化與骨分化間質幹細胞對脊椎融合的效果。以膠原蛋白為載體的兔子實驗 |
(國科會共同主持人) |
|
|
結案 |
遞補學生事務與輔導人力計畫 (教育部) |
2009/01/01~2009/12/31 |
4,992,910元 |
|
結案 |
利用中草藥晶片技術針對特定天然物進行抗腎纖維化分析與TGF-beta/受器/受器後Smad相關路徑機轉探討（NSC 96-2314-B-273-002-MY3 ）(國科會) |
2007/08/01~2010/07/31 |
2,680,000 元 |
|
結案 |
以活血中草藥杜牛膝分析抗纖維化有效成分 （99B-17-036 ）(教育部園區產學合作計劃) |
2010/01/25~2010/12/31 |
940,500 元 (MOE35,IND40) |
|
結案 |
以台灣血藤進行抗腎纖維化有效成分之專利開發 (98B-17-025) (國科會/教育部) |
2009/01/01~2009/12/31 |
894,500 元 |
|
結案 |
學界協助中小企業科技關懷計畫診斷計畫書 (教育部/金屬中心) |
2009/01/01~2009/06/31 |
30,000 元 |
|
結案 |
建構中草藥活性活性成分篩選平台以提昇產業既有技術之經濟價值 (B-17-037) |
2008/06/01~2009/01/31 |
897,000元 |
|
結案 |
人類乳突病毒E2基因之研究 |
華產96 2008/01/01~2008/06/30 |
110,500 (配合25,500) |
|
結案 |
以生物晶片配合定量聚合酵素反應開發快速篩檢纖維化等疾病基因表現平台 |
華產96 2007/12/01~2008/05/31 |
133,900 (配合30,900 ) |
|
結案 |
探討第二型骨頭成型蛋白在糖尿病腎纖維化上治療的角色 |
NSC 95-2314-B273-003 |
814,000元 |
|
結案 |
中草藥指標、有效成分與標準品之研究與開發 (衛生署) |
CCMP95-TP-007 2006/5/26~2006/12/31 |
1342,000元 (配合400,000) |
|
結案 |
運用第二型血管加壓素抑制劑與第二型乙型轉型生長因子受器干擾性RNA之「雙重抑制策略」在糖尿病腎臟纖維化治療上之研究 |
NSC 94-2314-B273-001 |
816,000 元 |
|
結案 |
NSC 93-2314-B273-001 |
1,020,000 元 |
|
|
結案 |
NSC 92-2314-B273-001 |
650,000元 |
|
|
結案 |
以轉錄因子誘餌探討逆轉高度糖化終產物所誘導腎臟細胞thrombospondin-1過量表現與細胞病變的可行性 |
NSC 91-2314-B-273 -005 |
1,020,000元 |
|
結案 |
轉錄因子AP-1與NF-kappaB在高糖誘導腎小管細胞株之乙型轉型生長因子第二型受器表現所扮演的角色 |
NSC 90-2314-B-273-003 |
870,000元 |
國際受邀演講 (Invited speaker)
2013大陸海口國際新藥研發展 (11th Anniversary of International Drug Discovery Science and Technology, Therapy and EXPO): http://www.iddst.com/iddst2013/
2013澳洲布里斯本: http://web.pts.org.tw/macroview/news/searchresult.php?fid=34428
2013澳洲昆士蘭大學生物醫學研究所(SBMS, University of Queensland)
2013南韓首爾 (32nd Annual Meeting of the Korean Endocrine Society)
2013大陸河南省新鄉職業技術學院, 鄭州澍青醫學高等專科學校 (8.30-9.2)
學術論文發表 (Publications)
NEW
Yen-Hsi Lee, Richard C Wu, Hsing-Chia Mai , Wei-Lun Huang , Chun-Hsien Wu, Yu-Lin Yang , Pei-Fang Hsieh, Victor C Lin 2023 Apr The Regulatory Role of Nuclear Respiratory Factor 1 in Bladder Cancer Cells
Anticancer Res 2.0 ONCOLOGY - SCIE 210/241 1521-1531
Chun-Hsien Wu , Pei-Fang Hsieh , Yen-Hsi Lee , Wade Wei-Ting Kuo , Richard Chen-Yu Wu, Yung-Yao Lin , Chih-Hsin Hung , Ming-Lin Hsieh , See-Tong Pang , Yu-Lin Yang, Victor C Lin 2022 Sep-Oct Nuclear Respiratory Factor 1 Overexpression Inhibits Proliferation and Migration of PC3 Prostate Cancer Cells Cancer Genomics Proteomics 2.5 GENETICS & HEREDITY 108/171 614-623
Nuclear Respiratory Factor 1 Overexpression Inhibits Proliferation and Migration of PC3 Prostate Cancer Cells. Wu CH, Hsieh PF, Lee YH, Kuo WW, Wu RC, Lin YY, Hung CH, Hsieh ML, Pang ST, Yang YL, Lin VC. Cancer Genomics Proteomics. 2022 Sep-Oct;19(5):614-623. doi: 10.21873/cgp.20346.PMID: 35985685 (SCI 4.096)
Verbascoside inhibits the epithelial-mesenchymal transition of prostate cancer cells through high-mobility group box 1/receptor for advanced glycation end-products/TGF-β pathway. Chun-Hsien Wu 1 2 3, Chung-Hsien Chen 1 2 3, Pei-Fang Hsieh 1 4,
Yen-Hsi Lee 2 5, Wade Wei-Ting Kuo 1 2, Richard Chen-Yu Wu 1 6, Chih-Hsin Hung 2, Yu-Lin Yang 4 7, Victor C Lin 1 6 Environ Toxicol 2021 Jun;36(6):1080-1089. doi: 10.1002/tox.23107. Epub 2021 Feb 1. (SCI 4.119)
Macrophage migration inhibitory factor regulates integrin-β1 and cyclin D1 expression via ERK pathway in podocytes. Chen CA, Chang JM, Yang YL, Chang EE, Chen HC.Biomed Pharmacother. 2020 Apr;124:109892. doi: 10.1016/j.biopha.2020.109892. Epub 2020 Jan 24.PMID: 31986415 (SCI 6.529)
2. Angiotensin-converting enzyme inhibitors attenuated advanced glycation end products-induced renal tubular hypertrophy via enhancing nitric oxide signaling.Hwang JY, Kan WC, Liu YB, Chuang LY, Guh JY, Yang YL, Huang JS.J Cell Physiol. 2019 Mar 1. doi: 10.1002/jcp.28369. [Epub ahead
3. Chien-An Chena; Jer-Ming Changc; Eddy-Essen Changd; Hung-Chun Chend; Yu-Lin Yange. Crosstalk between transforming growth factor-β1 and endoplasmic reticulum stress regulates alpha-smooth muscle cell actin expression in podocytes. Life Sciences 209 (2018) 9–14
4. Chien-An Chena; Jer-Ming Changc; Eddy-Essen Changd; Hung-Chun Chend; Yu-Lin Yange. TGF-β1 modulates podocyte migration by regulating the expression of integrin-β1 and -β3 through different signaling pathways. Biomedicine & Pharmacotherapy 105 (2018) 974–980
5. Jue-LongWang,Chin-WangChen,Mu-RouTsai,Shu-FenLiu,Tsung-JeuHung,Yu-Ju-Hung,Wen-TengChang,Ming-DerShi,Pei-fang Hsieh, Yu-Lin Yang.Antifibrotic role of PGC-1α-siRNA against TGF-β1-induced renal interstitial fibrosis.Exp Cell Res.18 June 2018.
6. Pei fang Hsieh and Yu-Lin Yang. Renal Fibrosis and Mitochondrial Biogenesis. Diabetes, Metabolic Disorders & Control. November 10, 2016
7. Jue-Long Wang, Yi-Jyun-Chen, Pei-fang Hsieh, Shu-Fen Liu, Tsung-Jen Hung, Chien-Ya Hung, Ming-Der Shi, Yu-Ju Hung, Tzu-sui Hung, Yow-Ling Shiue, and Yu-Lin Yang. Verbascoside Reverses TGF-β1-Induced Renal Cellular Fibrosis. Metabolic Disorders & Control. October 28, 2016
8. Hsieh PF, Liu SF, Hung TJ, Hung CY, Liu GZ, Chuang LY, Chen MF, Wang JL, Shi MD, Hsu CH, Shiue YL, Yang YL. Elucidation of the therapeutic role of mitochondrial biogenesis transducers NRF-1 in the regulation of renal fibrosis. Experimental Cell Research . Nov 15, 2016. Ranking: 82/213
9. Pei-fang Hsieh; Shu-Fen Liu; Tsung-Jen Hung; Chien-Ya Hung; Guo-Zheng Liu; Lea-Yea Chuang; Mei-Fen Chen; Jue-Long Wang; Ming-Der Shi; Chen hung Hsu; Yow-Ling Shiue; Yu-Lin Yang. Treatment with cytokine thymic stromal lymphopoietin short hairpin RNA substantially reduces TGF-1-induced interstitial cellular fibrosis. Exp Cell Res. 2016 July (SCI 3.577) Ranking:82/213
10. Chien-Ya Hung, Shu-Jhen Ma, Shu-Fen Liu, Pei-fang Hsieh, Yu-Lin Yang. Water extract of Osmanthus Fragrans attenuates TGF-β1-induced lung cellular fibrosis in human lung fibroblasts cells." International Journal of Pharmacological Research.2015 (SCI:2.92)
11. Wang WC, Liu SF, Chang WT, Shiue YL, Hsieh PF, Hung TJ, Hung CY, Hung YJ, Chen MF, Yang YL*(corresponding). The effects of diosgenin in the Regulation of renal proximal tubular fibrosis. Exp Cell Res. 2014 May 1;323(2):255-62. doi: 10.1016/j.yexcr.2014.01.028. Epub 2014 Feb 10. (SCI 3.577)
12. Chen MF, Tsai JT, Chen LJ, Wu TP, Yang JJ, Yin LT, Yang YL, Chiang TA, Lu HL, Wu MC. Characterization of imidazoline receptors in blood vessels for the development of antihypertensiveagents. Biomed Res Int. 2014; 2014:182846. doi: 10.1155/2014/182846. Epub 2014 Apr 3. (SCI 2.880)
13. Chen MF, Tsai JT, Chen LJ, Wu TP, Yang JJ, Yin LT, Yang YL, Chiang TA, Lu HL, Wu MC. Antihypertensive action of allantoin in animals. Biomed Res Int. 2014;2014:690135. doi: 10.1155/2014/690135. Epub 2014 Mar 12 (SCI 2.880)
14. Tsung-Jen Hung1, Shu-Fen Liu1,2, Guo-Zheng Liu1, Pei-fang Hsieh3, Lea-Yea Chuang4, Jinn-Yuh Guh2, Chang-Chi Hsieh5, Yu-Ju Hung1,6, Yow-Ling Shiue3 and Yu-Lin Yang1,7*. shRNA for Thymic Stromal Lymphopoietin: A Novel Therapeutic Approach for Pulmonary Fibrosis Hung et al., J Cell Sci Ther 2013, 4:3 http://dx.doi.org/10.4172/2157-7013.1000144 (Accepted) 2013, Oct
15. Huang YH, Lin CC, Jhao CL, Yang YL, Lee TC. Polymerase Chain Reaction as the Sole Diagnostic Tool for Sacral-Spinal Tuberculosis. Surg Infect (Larchmt). 2013 Apr 5. [Epub ahead of print]
16. Ko YM, Chang CY, Chiou SJ, Hsu FJ, Huang JS, Yang YL, Guh JY, Chuang LY. Ubiquitin C-terminal hydrolase-L5 is required for high glucose-induced transforming growth factor-receptor I expression and hypertrophy in mesangial cells. Arch Biochem Biophys. 2013 Mar 12. doi:pii: S0003-9861(13)00084-2. 10.1016/j.abb.2013.03.003. [Epub ahead of print] PMID: 23500140
17. Shu-Fen Liu, Shan-Yu Chang, Tao-Chen Lee, Lea-Yea Chuang, Jinn-Yuh Guh, Chien-Ya Hung, Tsung-Jen Hung,Yu-Ju Hung, Po-Yi Chen, Pei-fang Hsieh,Yu-Lin Yang*. Dioscorea alata attenuates renal interstitial cellular fibrosis by regulating Smad- and epithelial-mesenchymal transition signaling pathways PLoS ONE (SCI 4.092) (Accepted Sep 17, 2012) (PONE-D-12-07869, 2012/4/27) [Ranking: 12/85 (14%) in biology field]
18. Hung TJ, Chen WM, Liu SF, Liao TN, Lee TC, Chuang LY, Guh JY, Hung CY, Hung YJ, Chen PY, Hsieh PF, Yang YL. 20-hydroxyecdysone attenuates TGF-β1-induced renal cellular fibrosis in proximal tubule cells. J Diabetes Complications. 2012 Aug 1, (SCI 2.032: “ENDOCRINOLOGY & METABOLISM” category.)[Ranking: 80/122 (65%) in ENDOCRINOLOGY & METABOLISM field]
19. Tsung-Jen Hung, Guo-Zheng Liu, Shu-Fen Liu, Tao-Chen Lee, Lea-Yea Chuang, Jinn-Yuh Guh, Chang-Chi Hsieh, Yu-Lin Yang. (P234). shRNA for Thymic Stromal Lymphopoietin as an Novel Antagonist for Pulmonary Fibrosis. Molecular Therapy (20), Supplement 1, S92, May 2012. The American Society of Gene & Cell Therapy (SCI 6.873: “BIOTECHNOLOGY & APPLIED MICROBIOLOGY” category.)
20. Yu-Lin Yang, Shu-Fen Liu, Guo-Zheng Liu, Jinn-Yuh Guh, Lea-Yea Chuang, Tao-Chen Lee, Ming-Chuan Hong, Tsung-Jen Hung, Zih-Han Yang, Pei-fang Hsieh. TSLP shRNA Attenuates TGF-β1-Induced Renal Interstitial Fibrosis. (P423). Molecular Therapy (20), Supplement 1, S165, May 2012. (SCI 6.873: “BIOTECHNOLOGY & APPLIED MICROBIOLOGY” category.) [Ranking: 9/158 in BIOTECHNOLOGY & APPLIED MICROBIOLOGY field] (Accepted Sep 17,2012) (PONE-D-12-07869, 2012/4/27) [Ranking: 9/158 (14%) in BIOTECHNOLOGY & APPLIED MICROBIOLOGY field]
21. Hsieh PF, Liu SF, Lee TC, Huang JS, Yin LT, Chang WT, Chuang LY, Guh JY, Hung MY, Yang YL (correspondance). The role of IL-7 in renal proximal tubule epithelial cells fibrosis. Mol Immunol. 2012 Feb; 50(1-2):74-82. (SCI 2.897: “BIOCHEMISTRY &
22. Yang YL, Ju HZ, Liu SF, Lee TC, Shih YW, Chuang LY, Guh JY, Yang YY, Liao TN, Hung TJ, Hung MY. BMP-2 suppresses renal interstitial fibrosis by regulating epithelial-mesenchymal transition. J Cell Biochem. 2011Sep;112(9):2558-65. (SCI 2.868: “BIOCHEMISTRY & MOLECULAR BIOLOGY” category.)[Ranking: 142/290 (48%) inBIOCHEMISTRY & MOLECULAR BIOLOGY field]
23. Lee TC, Wang CJ, Yang YL, Huang YH, Lin WC, Chang SY. Bone morphogenetic protein-2 expression in spinal fusion masses enhanced by extracorporeal shock wave treatment: a rabbit experiment. Acta Neurochir (Wien).2010, Oct; 152(10):1779-1784 (SCI 1.520: “SURGERY” category.)[Ranking: 86/199 (43%) in SURGERY field]
24. Ching-Jen Wang, Lin-Hsiu Weng, Shan-Ling Hsu, Yi-Chih Sun, Ya-Ju Yang, Yi-Sheng Chan, and Yu-Lin Yang, Ph.D (correspondance). pCMV–BMP-2–Transfected Cell– Mediated Gene Therapy in Anterior Cruciate Ligament Reconstruction in Rabbits. Arthroscopy: The Journal of Arthroscopic and Related Surgery, 26(7) : 968-976 (2010, July) (SCI 3.024: “ORTHOPEDICS” category.)[Ranking: 6/65 (9%) in ORTHOPEDICS field]
25. Chiang TA, Yang YL, Yang YY, Hu MH, Wu PF, Liu SF, Huang RM, Liao TN, Hung CY, Hung TJ, Lee TC. Hyperosmolarity enhanced susceptibility to renal tubular fibrosis by modulating catabolism of type I transforming growth factor-beta receptors. J Cell Biochem. 2010 Mar 1;109(4):663-71. (SCI 2.868: “BIOCHEMISTRY & MOLECULAR BIOLOGY” category.)[Ranking: 142/290 (48%) in BIOCHEMISTRY & MOLECULAR BIOLOGY field]
26. Chen SC, Guh JY, Hwang CC, Chiou SJ, Lin TD, Ko YM, Huang JS, Yang YL, Chuang LY. J Cell Biochem. 2010 Jan1;109(1):38-48.Advanced glycation end-products activate extracellular signal- regulated kinase via the oxidative stress-EGF receptor pathway in renal fibroblasts. (SCI 2.868: “BIOCHEMISTRY & MOLECULAR BIOLOGY” category.)
27. Yang YL (Corresponding author), Liu YS, Chuang LY, Guh JY, Lee TC, Liao TN, Hung MY, Chiang TA. Endocrinology. 2009 Feb;150(2):727-40. PMID: 18832104. Bone morphogenetic protein-2 antagonizes renal interstitial fibrosis by promoting catabolism of type I transforming growth factor-beta receptors. (SCI 4.459: “ENDOCRINOLOGY & METABOLISM” category.)[Ranking: 28/122 (22%) in ENDOCRINOLOGY & METABOLISM]
28. Lee TC, Chang NK, Su FW, Yang YL, Su TM, Lin YJ, Lin WC, Huang HY. Systemic and local reactions of a water-soluble copolymer bone on a bony defect of rabbit model Surg Neurol. 2009 Dec;72 Suppl 2:S75-9; discussion S79. Epub 2009 Aug 7.PMID: 19665194(SCI 1.669: “SURGERY” category.)[Ranking: 72/199 (36%) in SURGERY]
29. Lee TC, Yang YL, Chang NK, Lin TS, LinWC, Liu YS,Wang CJ. Biomechanical testing of spinal fusion segments enhanced by extracorporeal shock wave treatment in rabbits. Chang Gung Med J. 2009 May-Jun;32(3):276-82.PMID: 19527606
30. Huang JS, Chuang LY, Guh JY, Yang YL, Hsu MS. Effect of taurine on advanced glycation end products-induced hypertrophy in renal tubular epithelial cells. Toxicol Appl Pharmacol. 2008 Dec 1;233(2):220-6.Epub 2008 Sep 12.PMID: 18834896(SCI 4.447 : “TOXICOLOGY” category.)
31. Lee TC, Huang HY, Yang YL, Hung KS, Cheng CH, Lin WC, Wang CJ. Application of extracorporeal shock wave treatment to enhance spinal fusion: a rabbit experiment. Surg Neurol. 2008 Aug;70(2):129-34; discussion 134.PMID: 18640400 (SCI 1.669: “SURGERY” category.)[Ranking: 72/199 (36%) in SURGERY]
32. Yang YL (Corresponding author),*, Chang SY, Teng HC, Liu YS, Lee TC, Chuang LY, Guh JY, Chang FR, Liao TN, Huang JS, Yeh JH, Chang WT, Hung MY, Wang CJ, Chiang TA, Hung CY, Hung TJ. Safflower extract: A novel renal fibrosis antagonist that functions by suppressing autocrine TGF-beta. J Cell Biochem. 2008 Jan 11; [Epub ahead of print] PMID: 18189272. (SCI 2.868: “BIOCHEMISTRY & MOLECULAR BIOLOGY” category.)[Ranking: 142/290 (48%) in BIOCHEMISTRY & MOLECULAR BIOLOGY field]
33. Wang HC, Yang YL, Lin WC, ChenWF, Yang TM, Lin YJ, Rau CS, Lee TC. Computer- assisted pedicle screw placement for thoracolumbar spine fracture with separate spinal reference clamp placement and registration. Surg Neurol. 2008 Jan 17; PMID: 18207531 (SCI 1.669: “SURGERY” category.)[Ranking: 72/199 (36%) in SURGERY]
34. ChouWW, Guh JY, Tsai JF, Hwang CC, Chen HC, Huang JS, Yang YL, HungWC, Chuang LY. Arecoline-induced growth arrest and p21(WAF1) expression are dependent on p53 in rat hepatocytes. Toxicology. 2008 Jan 14;243(1-2):1-10. PMID: 17997002 (SCI 3.681 : “TOXICOLOGY” category.)[Ranking: 16/83 (19%) in TOXICOLOGY]
35. Yang YL (Corresponding author), Lin SH, Chuang LY, Guh JY, Liao TN, Lee TC, ChangWT, Chang FR, Hung MY, Chiang TA, Hung CY. CD36 is a novel and potential anti-fibrogenic target in albumin-induced renal proximal tubule fibrosis. J Cell Biochem. 2007 Jun 1;101(3):735-44. PMID: 17226761 (SCI 2.868: “BIOCHEMISTRY & MOLECULAR BIOLOGY” category.)[Ranking: 142/290 (48%) in BIOCHEMISTRY & MOLECULAR BIOLOGY field]
36. Lee TC, Huang HY, Yang YL, Hung KS, Cheng CH, Chang NK, Chung YH, Hu MS,Wang CJ. Vulnerability of the spinal cord to injury from extracorporeal shock waves in rabbits. J Clin Neurosci. 2007 Sep;14(9):873-8. PMID: 17660057 (SCI 1.247 : “CLINICAL NEUROLOGY” category.)[Ranking: 147/192 (76%) in CLINICAL NEUROLOGY]
37. Chen YH, Guh JY, Chuang TD, Chen HC, Chiou SJ, Huang JS, Yang YL, Chuang LY. High glucose decreases endothelial cell proliferation via the extracellular signal regulated kinase/p15(INK4b) pathway. Arch Biochem Biophys. 2007 Jun 4; PMID: 17597576 (SCI 2.935: “BIOPHYSICS” category.)[Ranking: 35/74 (47%) in BIOPHYSICS]
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